• RNAi Global Initiative

    The RNAi Global Initiative represents an unprecedented venture bringing together a group of visionary research institutions and investigators to harness the potential of RNA interference as an important functional genomic tool.

    Through collaboration and the meaningful exchange of information and data, we intend to draw a comprehensive roadmap of human gene function and use this as a foundation to revolutionize the way medicine and healthcare are delivered.

    To this end, members of the RNAi Global Initiative are actively engaged in promoting the concept and implementation of minimum information standards to facilitate data sharing within the extended RNAi community.  Building on established standards such as MIAME (Minimum Information About a Microarray Experiment), the RNAi Global Initiative has contributed work towards a community-wide effort known as the Minimum Information About an RNAi Experiment (MIARE).  These reporting guidelines were developed in part by a large inter-laboratory benchmarking study and in part by workshops and discussions amongst the RNAi Global Initiative members.  For more detailed information and to provide input, please visit http://www.miare.org.

  • What is RNA Interference?

    RNA interference involves the use of specialized RNA molecules known as small interfering RNA (siRNA).  Seen here is a depiction of an siRNA molecule, learn more about how RNA interference works.

  • Upcoming Events of Interest

    Discovery On Target

    Boston, MA, USA
    View Meeting Website

    26-28 September, 2017

  • Recent Member Publications

    Dutta B, et al. (2016) An interactive web-based application for Comprehensive Analysis of RNAi-screen Data. Nat Commun. 2016 Feb 23;7:10578.

    Evers, et al. (2016) CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes. Nat Biotechnol. 2016 Jun;34(6):631-3.