Dhiraj Kumar

Dhiraj Kumar ICGEB-ND_Dhiraj_Kumar 

Staff Research Scientist  



Brief biography: 

Education: Indian Agricultural Research Institute, New Delhi, India (MSc, 2002)
International Centre for Genetic Engineering and Biotechnology, New Delhi, India, (PhD, 2007)


Career History: 

Since 2010: Staff Research Scientist, Immunology Group, ICGEB, New Delhi, India
2007-2010: Research Scientist, Immunology Group, ICGEB, New Delhi, India 

2002-2007: Graduate Student, Immunology Group, ICGEB, New Delhi, India 



2009-10: Innovative Young Biotechnologist Award (IYBA), DBT, Govt. of India 

2002: Shyama Prasad Mukherjee (SPM) Award, CSIR, India 

2003: IARI Gold Medal for outstanding academic record and research during Msc. 


Contact Information:  

Dhiraj Kumar 

International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
New Delhi-110067, 


E-mail: dhiraj@icgeb.res.in, dhirajkrverma@gmail.com
Tel: +91-11-26741358/26741361/26742357/26742360 ext. 113
Fax: +91-11-26715114 


Research Focus:  

  • Understanding Host-Pathogen Interactions in case of Mycobacterium tuberculosis infection using high throughput experimentation and integrative (global) analytical approaches 
  • Dynamic Modeling of Signaling Events in Biological Systems and Design Principles of Biological Networks. 


Areas of Expertise: 


Experimental: Related to - Signaling events, Proteomics, Mycobacterium tuberculosis infection, siRNA knock-down, Gene expression (Micro-array), Confocal Microscopy and Live Cell Imaging 


Analytical: Mathematical models, Network based models, Dynamic Models, Multivariate analysis, Statistical models, Micro-array analysis. 



Relevant Publications:  


1. Kumar, D., and Rao, K. V. (2010). Regulation between survival, persistence, and elimination of intracellular mycobacteria: A nested equilibrium of delicate balances. Microbes Infect. doi:10.1016/j.micinf.2010.10.009 


2. Kumar, D., Nath, L., Kamal, M. A., Varshney, A., Jain, A., Singh, S., and Rao, K. V. (2010) Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis. Cell 140, 731-743. 


3. Jayaswal, S., Kamal, M.A., Dua, R., Gupta, S., Majumdar, T., Das, G., Kumar, D1. And Rao, K.V.S.1 (2010) Identification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screen. PLoS Pathogen 6(4): e1000839 (1Joint Communicating Authors).  


4. Chaudhri VK, Kumar D, Misra M, Dua R, & Rao KV (2010) Integration of a phosphatase cascade with the mitogen-activated protein kinase pathway provides for a novel signal processing function. J Biol Chem 285(2):1296-1310. 


5. Basu, S. K., Kumar, D., Ganguly, N., Rao, K. V., and Sharma, P. (2009). Mycobacterium tuberculosis secreted antigen (MTSA-10) inhibits macrophage response to lipopolysaccharide by redox regulation of phosphatases. Indian J Exp Biol 47, 505-519. 


6. Kumar, D., Dua, R., Srikanth, R., Jayaswal, S., Siddiqui, Z., and Rao, K. V. (2008). Cellular phosphatases facilitate combinatorial processing of receptor-activated signals. BMC Res Notes 1, 81. 


7. Kumar, D., Srikanth, R., Ahlfors, H., Lahesmaa, R., and Rao, K. V. (2007). Capturing cell-fate decisions from the molecular signatures of a receptor-dependent signaling response. Mol Syst Biol 3, 150. 


8. Basu, S. K., Kumar, D., Singh, D. K., Ganguly, N., Siddiqui, Z., Rao, K. V., and Sharma, P. (2006). Mycobacterium tuberculosis secreted antigen (MTSA-10) modulates macrophage function by redox regulation of phosphatases. Febs J 273, 5517-5534. 


9. Singh, D. K., Kumar, D., Siddiqui, Z., Basu, S. K., Kumar, V., and Rao, K. V. (2005). The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal. Cell 121, 281-293.