The VU University Medical Center (VUmc) is the academic medical center of the VU University in Amsterdam, the Netherlands. The VUmc is specialized in helping patients with uncommon clinical pictures and those who require highly intensive and complex care. The VUmc offers tertiary clinical care and referral-center care in certain areas. This often involves unique diagnosis and treatment, and specialized research. The VUmc contributes to the maintenance and improvement of public health by conducting research, disseminating new knowledge, and by educating a new generation of care providers. The scientific research at VUmc is based on five pivotal points, which are embodied by multidisciplinary research institutes. Research in the area of cancer and immunology is organized in the VUmc Institute for Cancer and Immunology (V-ICI). V-ICI participates in two research and graduate schools accredited by the Royal Netherlands Academy of Arts and Sciences, i.e., the Oncology Graduate School Amsterdam and the Amsterdam-Leiden Institute for Immunology.
The VUmc Cancer Center Amsterdam (CCA) is the cancer expertise center of the VUmc. The CCA aims to provide the best possible care and treatment to patients with cancer. To this end, the CCA integrates and strengthens oncology expertise at the VUmc, stimulating translation of basic research programs into clinical useful tools and methods. In 2006, CCA and V-ICI merged and opened a new research building where most basic and translational oncology research being conducted at VUmc is clustered. In addition, it was decided to complement existing core facilities for microarray and proteomics research by establishing a core facility for RNAi library screening. This RNA Interference
Functional Oncogenomics Laboratory (RIFOL) was set up with financial support from the Foundation SBGO, one of the foundations supporting CCA/V-ICI. The RIFOL serves a wide range of labs at VUmc and represents VUmc as member of the RNAi Global Initiative.
For further information, visit our website at http://www.vumc.com.
RNAi Global Principal Investigators
Victor W. van Beusechem, Ph.D.
Dept. Medical Oncology, section Oncogenomics/RIFOL
Identification of genes involved in oncolytic virus replication in cancer cells.
Web (1), Web (2)
Email
|
Jacqueline Cloos, Ph.D.
Dept. Pediatric Oncology/Hematology
Find new treatment targets in relevant signal transduction pathways for innovative therapy of leukemia.
Web (1), Web (2)
Email
|
Gerrit A. Meijer, MD Ph.D.
Dept. Pathology, Tumor Profiling Unit
Identification of genes that drive colon adenoma-to-carcinoma progression.
Web
Email
|
Johan de Winter, Ph.D.
Dept. Clinical Genetics
Chromosomal instability and cancer, with a focus on inherited cancer predisposition syndromes.
Email
|
Linda Smit
Dept.Hematology
Identification of factors specific for leukemic stem cells of Acute
Myeloid Leukemia and Chronic Myeloid Leukemia
Web
Email
|
Teunis B.H. Geijtenbeek, Ph.D.
Dept. Molecular Cell Biology and Immunology
Defining molecular mechanisms of immune subversion by pathogens and tumors.
Email |
Renske D.M. Steenbergen, Ph.D.
Dept. Pathology, Molecular Pathology Unit
Elucidation of human papillomavirus (HPV)-mediated carcinogenesis of the uterine cervix and translation of this basic knowledge into novel approaches for prevention and treatment of cervical cancer.
Email
|
Thomas Wurdinger, Ph.D.
Dept. Neurosurgery, Neuro-ocology Research Group (NRG)
Identification of genes involved in brain tumor systems.
Email |
Ruud H. Brakenhoff, Ph.D.
Dept. Otolaryngology/Head and Neck Surgery
Identification of genes involved in HNSCC carcinogenesis and genes modulating chemoradiation resistance in head and neck cancer
Email |
|
Primary Contact Information
Victor W. van Beusechem, Ph.D.
RNAi Functional Oncogenomics Laboratory
Department of Medical Oncology
Phone: +31.20.444.2162
Fax: +31.20.444.2126
Web (1), Web (2)
Email
Institutional Contact
Laura Scheenloop and Joke van Diemen
Office of the Director Dr. W.R. Gerritsen
VUmc CCA / V-ICI
Phone: +31 20 4444 342 or +31 20 4444 356
Fax: +31 20 4444 081
Email