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| Samuel Lunenfeld Research Institute at Mount Sinai Hospital | |||||||||
| Jeffrey Wrana | |||||||||
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Dr. Jeffrey Wrana is a Senior Investigator at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital
and a Professor in the Department of Medical Genetics and Microbiology at the University of Toronto.
Using high-throughput proteomics and genetic tools, Dr. Wrana's research program seeks to understand morphogen
signaling pathways, the higher organizational structure, or network into which they are integrated and how
these systems control cell behaviour in development and cancer.
Dr. Wrana received his PhD in biochemistry in 1991 from the University of Toronto, and completed postdoctoral training at the Memorial Sloan-Kettering Cancer Center in New York. He is a Howard Hughes Medical Institute International Research Scholar (2002-6) and has been awarded a number of priizes for his research excellence, including the William E. Rawls Prize from the National Cancer Institute of Canada (1998), the Merck Frosst Prize from the Canadian Society of Biochemistry Molecular and Cell Biology (2002) and the Paul Marks Prize from Memorial Sloan Kettering Institute (2005). With genome sequences now available, the tools are in hand to explore the dynamic organization of protein networks, and cellular organization. Ours goals are to understand how networks of genes and proteins interact to organize cellular function and how biological systems behave over time and under various conditions. What are the strategies that allow biological systems to withstand genetic variation and adapt to environmental change? How are genetic and protein networks perturbed in disease, and how we can use the tools of systems biology to create new paradigms in the treatment of human disorders? Scientists at the Samuel Lunenfeld Research Institute (SLRI) are leaders in the development of high throughput projects, and genome-wide assays are being employed to probe these questions. Our Robotics core facility at SLRI supports the work of scientists focusing on Mass Spectrometry and Proteomics, Bioinformatics, Center for Modeling Human Disease and Cell Biology. |
Dr. Jeffrey Wrana Contact Details Jim Dennis Dan Durocher Tony Pawson Jeff Wrana Samuel Lunenfeld Research Institute 600 University Avenue, Toronto Ontario, Canada M5G 1X5 Phone: 416-586-4800; extension 8233 Fax: 416-586-8857 |
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The Facility has an integrated screening platform for running fully automated assays:
Recent Publications Seliktar, D., Zisch, A.H., Lutolf, M.P., Wrana, J.L. and Hubbell, J.A. (2004). MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing. J Biomed. Mater. Res., 68A, 704-716. Kimura, Y., Jones N., Kluppel M., Hirashima M., Tachibana K., Cohn J.B., Wrana J.L., Pawson T. and Bernstein, A. (2004). Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages. Proc. Natl. Acad. Sci., 101, 6015-6020. Chong P.A., Ozdamar B., Wrana J.L., Forman-Kay J.D. (2004). Disorder in a target for the Smad2 mad homology 2 domain and its implications for binding and specificity. J. Biol. Chem., 279, 40707-40714. Von Both, I., Silvestri, C., Erdemir, T., Lickert, H., Walls, J., Henkelman, M., Rossant, J., Harvey, R.P., Attisano, L. and Wrana, J.L. (2004). Foxh1 is Essential for Development of the Anterior Heart Field. Dev. Cell, 7, 331-345. Swallow, C.J., Partridge, E.A., Macmillan, J.C., Tajirian, T., DiGuglielmo, G.M., Hay, K., Szweras, M., Jahnen-Dechent, W., Wrana, J.L., Redston, M., Gallinger, S. and Dennis, J.W. (2004). Alpha2HS-glycoprotein, an antagonist of Transforming Growth Factor beta in vivo, inhibits intestinal tumour progression. Cancer Res., 15, 6402-6409 Partridge, E.M., Le Roy, C., Di Guglielmo, G.M., Pawling, J., Cheung, P., Granovsky, M., Nabi, I.R., Wrana, J.L. and Dennis, J.W. (2004). Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science, 306, 120-124. Lickert, H., Takeuchi, J.K.,, von Both, I., Walls, J., McAuliffe, F., Adamson, S.L., Wrana, J.L., Henkelman, R.M., Rossant, J. and Bruneau, B.G. (2004). Baf60c confers tissue specificity to the Swi/Snf complex in heart and muscle development. Nature, 432, 107-112. Lee-Hoeflich, S.T.*, Causing, C.*, Zhao, X, Wrana, J.L. and Attisano, L. (2004). LIMK binding to the BMP receptor is required for BMP-dependent dendritogenesis. EMBO J., 23, 4792-4801. (* co-first authors) Barrios-Rodiles, M., Brown, K.R., Ozdamar, B., Liu, Z., Donovan, R.S., Shinjo, F., Liu, Y., Bose, R., Dembowy, J., Taylor, I.W., Luga, V., Przulj, N., Robinson, M., Suzuki, H., Hayashizaki, Y., Jurisica, I. and Wrana, J.L. (2005). High-Throughput Mapping of a Dynamic Signaling Network In Mammalian Cells. Science, 307, 1621-1625. Ozdamar, B.*, Bose, R.*, Barrios-Rodiles, M., Wang, H.-R., Zhang, Y. and Wrana, J.L. (2005). Regulation of Par6 by the TGFß receptor controls epithelial cell plasticity. Science, 307, 1603-1609. (* co-first authors) Pece-Barbara, N., Vera, S., Kathirkamathamby, K., Liebner S., Di Guglielmo, G.M., Dejana, E., Wrana, J.L. and Letarte, M. (2005). Endoglin null endothelial cells proliferate faster, and more responsive to TGFß 1 with higher affinity receptors and an activated ALK1 pathway. J. Biol. Chem., 280, 27800-8. Le Roy, C, and Wrana, J.L. (2005) Signaling and endocytosis: a team effort for cell migration. Dev Cell. 9, 167-8. Ogunjimi, A.A, Briant, D.J., Pece-Barbara, N., Le Roy, C., Di Guglielmo, G.M., Kavsak, P, Rasmussen, R.K., Seet, B.T., Sicheri, F., and Wrana, J.L. (2005). Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT Domain. Mol Cell. 19, 297-308. Kluppel, M., Wight, T.N., Hinek, A. and Wrana, J.L. (2005). Maintenance of chondroitin sulfonation balance by Chondroitin-4-sulfotransferase-1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis. Development. 132, 3989-4003. Varga, A.C. and Wrana, J.L. (2005) The disparate role of BMP in stem cell biology. Oncogene. 24, 5713-21. Reviews, Published Proceedings and Chapters Reguly, T. and Wrana, J.L. (2003). In or out? The dynamics of Smad nucleocytoplasmic shuttling. Trends Cell Biol., 13, 216-220. Zhang, Y., Wang, H.-R., and Wrana, J.L. (2004). Smurf1: A link between cell polarity and ubiquitination. Cell Cycle, 3, 391-392. Le Roy, C. and Wrana, J.L. (2004). Cell Biology: An unexpected social servant. Nature News and Views, 431, 142. Le Roy, C. and Wrana, J.L. (2005). The importance of location in signal transduction. Nat. Rev. Mol. Cell Biol., 6, 112-126. Kluppel, M. and Wrana, J.L. (2005). Turning it up a notch: cross-talk between TGFß and Notch signalling. Bioessays, 27, 115-118. Back to University of Toronto |
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