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German Cancer Research Center, DKFZ
	Michael Boutros
	The Group of Dr. Michael Boutros is part of the Functional Genomics Programme at the German Cancer Research Center (DKFZ) in Heidelberg. Our group is interested in the systematic analysis of signaling transduction pathways are essential for development and homeostasis in all higher organisms. Communication among cells is one of the most crucial processes that control a broad spectrum of biological functions including immune responses, cell differentiation, proliferation, and death. Dysregulation of signaling pathways has many severe consequences, leading to developmental defects and aberrant proliferation of cells that can cause cancer. During the past years, the sequencing of the human genome and the genomes of model organisms led to the discovery of several ten thousand genes, many with unknown functions. One of our main research aims is to develop and apply systematic reverse genetic screens by RNA interference to characterize gene function on a genome-wide scale with a focus on conserved and disease-relevant signaling pathways. For more information visit the Boutros Lab webpage
	Recent Publications Gesellchen, V., D. Kuttenkeuler, M. Steckel, N. Pelte, and M. Boutros. (2005). An RNAi screen identified a Role for IAP2 in Innate Immune Response in Drosophila. View at EMBO reports. Muller, P., D. Kuttenkeuler, V. Gesellchen, M. Zeidler, and M. Boutros. (2005). Identification of JAK/STAT signaling components by genome-wide RNAi. Nature 436:871-5. Arziman, Z., T. Horn, M. Boutros. (2005). E-RNAi: A web application to design optimized RNAi constructs. Nucleic Acids Res. 33:W582-88. Kuttenkeuler D., M. Boutros. (2004). Genome-wide RNAi as a route to gene function in Drosophila. Brief Funct Genomic Proteomic 3:168-76. Boutros M., A. Kiger, S. Armknecht, K. Kerr, M. Hild, B. Koch, S. Haas, Heidelberg FlyArray, R. Paro and N. Perrimon (2004). Genome-wide RNAi Analysis of Cell Growth and viability in Drosophila. Science 303:832-835. Back to DKFZ

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