RNAi Global Initiative - Cambridge Institute for Medical Research

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University of Cambridge Institute for Medical Research

	Matthew Seaman

	Matthew Seaman obtained his BSc from Imperial College (London University) in 1991 and then studied for a PhD in Margaret Robinson's lab at Cambridge University graduating in 1995. After a three year postdoctoral tour of duty in Scott Emr's laboratory (University of California at San Diego) Matthew returned to Cambridge to start his own lab with funding from the Wellcome Trust. Matthew Seaman is currently an MRC senior research fellow investigating the molecular mechanisms of endosome-to-Golgi membrane transport. This pathway is essential in the recycling of lysosome hydrolase receptors and therefore is required for proper lysosome biogenesis. Matthew's research is currently focused on understanding the function of a protein complex called retromer that plays a vital role in the endosome-to-Golgi transport of the cation-independent mannose 6-phosphate receptor. Matthew's group studies retromer function in both mammalian and yeast using various techniques including fluorescence and electron microscopy, immunoprecipitation, protein transport assays, yeast genetics and other cell biological approaches. Recent publications Collins, B.M., Skinner, C.F., Watson, P.J., Seaman, M.N.J. and Owen, D.J. (2005).Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly. Nat Struct Mol Biol. 12(7), 594-602. Seaman, M.N.J. (2005). Recycle your receptors with retromer. Trends Cell Biol. 15(2), 68-75. Seaman, M.N.J. (2004). Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J. Cell Biol. 165(1),111-22. Back to University of Cambridge