RNAi Global Initiative - University of Texas Southwestern Medical Center

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University of Texas Southwestern Medical Center

	Michael White

	Michael White, Ph.D., is an associate professor of cell biology at UT Southwestern Medical Center. He received his Ph.D. in biology at the University of North Carolina, Chapel Hill, where he studied DNA metabolism and meiotic recombination. The goal of his research is to uncover the mechanisms by which cells react to their environment. Aberrant regulation of these mechanisms can cause a wide variety of human diseases, including cancer. His work has focused on the class of proteins that integrate extracellular and intracellular cues to activate appropriate machinery driving the response of cells to those cues. He is using this information to describe the nature of signal-mediated information flow and connectivity to cell biological responses. With respect to human disease, he is translating his observations into a molecular understanding of the establishment of a minimal tumorigenic platform in general and human cancer in particular.

	Michael Roth, Ph.D., is a professor of biochemistry at UT Southwestern Medical Center. He received his graduate degree from the University of Alabama at Birmingham for work on the maturation of enveloped viruses in epithelial cells. His laboratory has worked on many aspects of intracellular membrane protein traffic, most recently on identifying targets of natural products with potential as leads for development as cancer therapeutics. Dr. Roth holds the Diane and Hal Brierley Chair in Biomedical Research at UT Southwestern, and he directs the High-Throughput Screening Laboratory at UT Southwestern.
	Contact Details Michael White Email Recent publications Moskalenko, S., Henry, D., Rose, C. Mirey, C., Camonis, J., and White, M. A. 2002. The exocyst is a Ral effector complex. Nature Cell Biology 4: 66-72. Chien, Y., and White, M. A. 2003. RalGTPases are linchpin modulators of human tumor cell proliferation and survival. EMBO Rep. 4:800-806. Matheny, S., Chen, C., Kortum, R., Razidlo, G., Lewis, R., and White, M. A. 2004. Ras regulates assembly of mitogenic signaling complexes through the novel effector protein IMP. Nature, 427: 256-260. Bumeister, R., Rosse, C., Anselmo, A., Camonis, C., and White, M. A. 2004. CNK2 Couples NGF Signal Propagation to Multiple Regulatory Cascades Driving Cell Differentiation. Current Biology, 14: 439-445. Camonis, J. H., and White, M. A. 2004. RalGTPases: corrupting the exocyst in cancer. Trends Cell Biol. 15: 327-332. Feng, Y., S. Yu, T. K. R. Lasell, A. P. Jadhav, E. Macia, P. Chardin, P.Melancon, T. Mitchitson, M. G. Roth, T. Kirchausen. 2003. Exo1, a new chemical inhibitor of the secretory pathway. Proc. Natl. Acad. Sci. USA 100:6469-74. Song, X.S., D. Padron-Perez, X. Liao, J. Wang, M. G. Roth and J. De Brabander. 2004. Salicylihalamide A inhibits the V0 sector of the V-ATPase through a mechanism distinct from bafilomycin A. J. Biol. Chem. 279:19755-63 Walter, M, N. Forsyth, W. Wright, J. Shay and M. G. Roth. 2004. The establishment of telomerase-immortalized Tangier Disease cell lines indicates the existence of an apolipoprotein AI-inducible but ABCA1-independent cholesterol efflux pathway. J. Biol. Chem. 279: 19755-19763. Koldamova, R.P, I. M. Lefterov, M. Staufenbiel, D. Wolfe, S. Huang, J. C. Glorioso, M. Walter, M. G. Roth and J. S. Lazo. 2004. The LXR ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease. J. Biol, Chem. 280:4079-4088. Baldwin, J., C. H. Michnoff, N. A. Malmquist, J. White, M. G. Roth, P. K Rathod and M. A. Phillips. 2005. High-throughput screening for potent and selective inhibitors of Plasmodiumn falciparum dihyrdroorotate dehydrogenase. J. Biol. Chem. 280: 21847-21853. Back to University of Texas Southwestern Medical Center