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Relevant Publications
Le Blanc, I., Luyet, P.P., Pons, V., Ferguson, C., Emans, N., Petiot, A., Mayran, N., Demaurex, N., Faure, J., Sadoul, R., Parton, R.G. and Gruenberg, J. (2005) Endosome-to-cytosol transport of viral nucleocapsids. Nat Cell Biol, 7, 653-664.
Paciorek, T., Zazimalova, E., Ruthardt, N., Petrasek, J., Stierhof, Y.D., Kleine-Vehn, J., Morris, D.A., Emans, N., Jurgens, G., Geldner, N. and Friml, J. (2005) Auxin inhibits endocytosis and promotes its own efflux from cells. Nature, 435, 1251-1256.
Ruthardt, N., Gulde, N., Spiegel, H., Fischer, R. and Emans, N. (2005) Four-dimensional imaging of transvacuolar strand dynamics in tobacco BY-2 cells. Protoplasma, 225, 205-215.
Voigt, B., Timmers, A.C., Samaj, J., Hlavacka, A., Ueda, T., Preuss, M., Nielsen, E., Mathur, J., Emans, N., Stenmark, H., Nakano, A., Baluska, F. and Menzel, D. (2005) Actin-based motility of endosomes is linked to the polar tip growth of root hairs. Eur J Cell Biol, 84, 609-621.
Antoine, M., Wirz, W., Tag, C.G., Mavituna, M., Emans, N., Korff, T., Stoldt, V., Gressner, A.M. and Kiefer, P. (2005) Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells. Growth Factors, 23, 87-95.
Zeiffer, U., Schober, A., Lietz, M., Liehn, E.A., Erl, W., Emans, N., Yan, Z.Q. and Weber, C. (2004) Neointimal smooth muscle cells display a proinflammatory phenotype resulting in increased leukocyte recruitment mediated by P-selectin and chemokines. Circ Res, 94, 776-784.
Black, S., Kadyrov, M., Kaufmann, P., Ugele, B., Emans, N. and Huppertz, B. (2004) Syncytial fusion of human trophoblast depends on caspase 8. Cell Death Differ, 11, 90-98.
Schillberg, S., Fischer, R. and Emans, N. (2003) Molecular farming of recombinant antibodies in plants. Cell Mol Life Sci, 60, 433-445.
Schillberg, S., Fischer, R. and Emans, N. (2003) 'Molecular farming' of antibodies in plants. Naturwissenschaften, 90, 145-155.
Jaag, H.M., Kawchuk, L., Rohde, W., Fischer, R., Emans, N. and Prufer, D. (2003) An unusual internal ribosomal entry site of inverted symmetry directs expression of a potato leafroll polerovirus replication-associated protein. Proc Natl Acad Sci U S A, 100, 8939-8944.
Emans, N., Zimmermann, S. and Fischer, R. (2002) Uptake of a fluorescent marker in plant cells is sensitive to brefeldin A and wortmannin. Plant Cell, 14, 71-86.
Di Fiore, S., Li, Q., Leech, M.J., Schuster, F., Emans, N., Fischer, R. and Schillberg, S. (2002) Targeting tryptophan decarboxylase to selected subcellular compartments of tobacco plants affects enzyme stability and in vivo function and leads to a lesion-mimic phenotype. Plant Physiol, 129, 1160-1169.
Fischer, R. and Emans, N. (2000) Molecular farming of pharmaceutical proteins. Transgenic Res, 9, 279-299; discussion 277.
Fischer, R., Hoffmann, K., Schillberg, S. and Emans, N. (2000) Antibody production by molecular farming in plants. J Biol Regul Homeost Agents, 14, 83-92.
Fischer, R., Emans, N., Schuster, F., Hellwig, S. and Drossard, J. (1999) Towards molecular farming in the future: using plant-cell-suspension cultures as bioreactors. Biotechnol Appl Biochem, 30 (Pt 2), 109-112.
Fischer, R., Liao, Y.C., Hoffmann, K., Schillberg, S. and Emans, N. (1999) Molecular farming of recombinant antibodies in plants. Biol Chem, 380, 825-839.
Fischer, R., Drossard, J., Commandeur, U., Schillberg, S. and Emans, N. (1999) Towards molecular farming in the future: moving from diagnostic protein and antibody production in microbes to plants. Biotechnol Appl Biochem, 30 (Pt 2), 101-108.
Fischer, R., Drossard, J., Emans, N., Commandeur, U. and Hellwig, S. (1999) Towards molecular farming in the future: pichia pastoris-based production of single-chain antibody fragments. Biotechnol Appl Biochem, 30 (Pt 2), 117-120.
Fischer, R., Vaquero-Martin, C., Sack, M., Drossard, J., Emans, N. and Commandeur, U. (1999) Towards molecular farming in the future: transient protein expression in plants. Biotechnol Appl Biochem, 30 (Pt 2), 113-116.
Biwersi, J., Emans, N. and Verkman, A.S. (1996) Cystic fibrosis transmembrane conductance regulator activation stimulates endosome fusion in vivo. Proc Natl Acad Sci U S A, 93, 12484-12489.
Emans, N., Nzala, N.N. and Desjardins, M. (1996) Protein phosphorylation during phagosome maturation. FEBS Lett, 398, 37-42.
Emans, N. and Verkman, A.S. (1996) Real-time fluorescence measurement of cell-free endosome fusion: regulation by second messengers. Biophys J, 71, 487-494.
Emans, N., Biwersi, J. and Verkman, A.S. (1995) Imaging of endosome fusion in BHK fibroblasts based on a novel fluorimetric avidin-biotin binding assay. Biophys J, 69, 716-728.
Emans, N., Gorvel, J.P., Walter, C., Gerke, V., Kellner, R., Griffiths, G. and Gruenberg, J. (1993) Annexin II is a major component of fusogenic endosomal vesicles. J Cell Biol, 120, 1357-1369.
Research Focus
High content genomics of GPCRs and NFκB: models include Endothelin A; mu, kappa, and delta Opioid; Galanin 1 and 3; Adenosine 1 and 3; muscarinic; acetylcholine 1,2,4 and 5;
and models for housekeeping endocytosis.
Contact Details
Neil Emans
E-mail
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Neil Emans