RNAi Global Initiative - Cambridge Institute for Medical Research

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University of Cambridge Institute for Medical Research

	Paul Luzio

	Paul Luzio has BA and PhD degrees from the University of Cambridge where he studied biochemistry. After a few years away from Cambridge he returned and became a University Lecturer in the Department of Clinical Biochemistry in 1979. In 1996 he was promoted to Reader and in 2001 to Professor of Molecular Membrane Biology. He moved to CIMR in 1998 and became Director in 2002. Paul is a Fellow of the Royal College of Pathologists and a Fellow of the Academy of Medical Sciences. Paul Luzio's present research interests are in understanding the biogenesis and function of lysosomes. They include (i) investigation of the sorting and delivery of lysosomal membrane proteins; (ii) investigating the protein machinery for sorting ubiquitinated, endocytosed membrane proteins into the lumenal vesicles of multi-vesicular bodies; (iii) understanding how fusion events involving lysosomes are regulated; (iv) understanding how abnormalities of traffic in the late endocytic pathway may lead to disease. The expertise in our research group includes subcellular fractionation, immunoisolation, cell-free assays, immunolocalisation at the light and electron microscope levels, flow cytometry, live cell imaging, molecular cell biology of membrane proteins. Recent publications Poupon, V., Stewart, A., Gray, S.R., Piper, R.C. & Luzio, J.P. (2003) The role of mVps18p in clustering, fusion and intracellular localization of late endocytic organelles. Mol. Biol. Cell 14: 4015-4027. Kyttälä, A., Ihrke, G., Vesa, J., Schell, M.J. & Luzio, J.P. (2004) Two motifs target Batten disease protein CLN3 to lysosomes in non-neuronal and neuronal cells. Mol. Biol. Cell 15: 1313-1323. Pryor, P.R., Mullock, B.M., Bright, N.A., Lindsay, M.R., Gray, S.R., Richardson, S.C.W., Stewart,A., James, D. E., Piper, R.C. & Luzio, J.P. (2004) Combinatorial SNARE complexes with either Vamp 7 or Vamp 8 define different late endocytic fusion events. EMBO Reports 5: 590-595. Ihrke, G., Kyttälä, A, Russell, M.R.G., Rous, B.A. & Luzio, J.P. (2004) Differential use of two AP-3-mediated pathways by lysosomal membrane proteins. Traffic 5: 946-962. Bright, N.A., Gratian, M. J. & Luzio, J.P. (2005) Endocytic delivery to lysosomes mediated by concurrent fusion and kissing events in living cells. Current Biology 15: 360-365. Kyttälä, A., Yliannala, K., Schu, P., Jalanko, A. & Luzio, J.P. (2005) AP-1 and AP-3 facilitate lysosomal targeting of Batten disease protein CLN3 via its dileucine motif. J. Biol. Chem. 280: 10277-10283. Contact Details Professor J. Paul Luzio University of Cambridge Cambridge Institute for Medical Research Wellcome Trust/MRC Building Addenbrooke's Hospital Hills Road, Cambridge CB2 2XY, UK Phone: (44) 1223 336780 Fax: (44) 1223 762630 e-mail: jpl10@cam.ac.uk Back to University of Cambridge