RNAi Global Initiative - Cambridge Institute for Medical Research

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University of Cambridge Institute for Medical Research

	Paul Lehner

	Paul Lehner trained in medicine at University College London and after specialist training in Infectious Diseases obtained his PhD from the University of Wales College of Medicine. He was a Wellcome Trust Postdoctoral Fellow in the Department of Immunobiology at the University of Yale and returned to the UK in 1998 on a Wellcome Trust Senior Fellowship to work at the Cambridge Institute of Medical Research (CIMR). He is a consultant in Infectious Diseases at Addenbrooke's Hospital, Cambridge and is a principal investigator in the CIMR. In 2003 he was promoted to Reader and in 2005 to Professor of Immunology and Medicine. Paul is a Fellow of the Royal College of Physicians and in 2004 was elected to the Academy of Medical Sciences. Paul Lehner's research interests include (i) the role of ubiquitin in the regulation of cell surface receptor expression, including identification of ubiquitin E3 ligases, ubiquitin E2 conjugating enzymes and deubiquitinating enzymes involved in this process (ii) identification of the endosomal sorting machinery used by internalised, ubiquitinated cell surface receptors (iii) mechanisms used by viruses to evade immune recognition, particularly of the MHC class I antigen presentation pathway and (iv) identification of receptors used by human and microbial heat shock proteins in dendritic cell signalling and activation. In our research group, expertise includes metabolic labeling, immunoprecipitation, and immunoisolation of membrane proteins, identification of substrates of ubiquitin E3 ligases, flow cytometry, retro- and lentiviral transduction systems and growth and manipulation of primary human dendritic cells. Recent publications Lehner PJ, Hoer S, Dodd R and Duncan LM (2005) Downregulation of Cell Surface Receptors by the K3 family of Viral and Cellular Ubiquitin E3 Ligases. Immunological Reviews 207:12-125 Boname, JM, deLima, BD, Lehner, PJ and Stevenson, PG (2004). Viral Degradation of the MHC class I peptide loading complex. Immunity 20:305-317. MacAry PA, Javid B, Floto RA, Smith KGC, Oehlmann W, Singh M and Lehner PJ (2004). HSP70 Peptide-Binding Mutants Separate Antigen Delivery From Dendritic Cell Stimulation Immunity 20: 95-106 Reeves MB, MacAry PA, Lehner PJ, Sissons JG, Sinclair JH (2005) Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers. Proc Natl Acad Sci 102(11):4140-5. Dodd, RB, Allen, MD, Brown, SE, Sanderson, CM, Duncan, L, Lehner, PJ, Bycroft, M and Read, R. (2004) Solution structure of the Kaposi's Sarcoma-associated Herpesvirus K3 N-terminal domain reveals a novel E2-binding C4HC3-type RING domain. Journal of Biological Chemistry 279 53840-53847. Hewitt, EW, Duncan, L, Mufti, D, Baker, J, Stevenson, P, and Lehner, PJ. (2002) Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation. EMBO Journal 21:2418 - 29. Contact Details Professor Paul J Lehner University of Cambridge Cambridge Institute for Medical Research Wellcome Trust/MRC Building Addenbrooke's Hospital Hills Road, Cambridge CB2 2XY, UK Phone: (44) 1223 762113 Fax: (44) 1223 762640 e-mail: pjl30@cam.ac.uk Back to University of Cambridge