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Renske D.M. Steenbergen, PhD, received her MSc degree in Biomedical Sciences at the University of Leiden, The Netherlands in 1991. In 1997 she received her PhD degree
at the VU University in Amsterdam, The Netherlands. In 1999, she was awarded a fellowship of the Royal Netherlands Academy of Arts and Sciences, which resulted in a
faculty position at the Dept. of Pathology at the VU University Medical Center in Amsterdam, the Netherlands.
The research of Renske Steenbergen and colleagues aims at the elucidation of human papillomavirus (HPV)-mediated carcinogenesis of the uterine cervix and translation
of this basic research knowledge into novel approaches for prevention and treatment of cervical cancer. This research line involves epidemiological, basic and
translational studies, using clinical specimens and model systems. For functional studies we developed a longitudinal in vitro model system of primary human keratincoytes
transfected with hrHPV types, in which the different stages of transformation (i.e. immortalization, anchorage independence and tumorigenicity) can be distinguished
(see Steenbergen et al., 1996, 2001, 2004). Studying genes involved in cervical carcinogenesis, will yield molecular markers that can be used to improve the efficacy
of cervical screening programs.
Selected Publications
Wilting SM, Snijders PJF, Meijer GA, Ylstra B, van den IJssel PRLA, Snijders AM, Albertson DG, Coffa J, Schouten JP, van de Wiel MA, Meijer CJLM, Steenbergen RDM.
Frequent gene copy number increases at chromosome 20q in both squamous cell carcinomas and adenocarcinomas of the cervix. J. Pathol 2006, published online March 2006
(in press).
Snijders PJF, Steenbergen RDM, Heideman DAM, Meijer CJLM. HPV-mediated cervical carcinogenesis: concepts and clinical implications.
J Pathol. 2006 Jan;208(2):152-64.
Heideman DAM, Steenbergen RDM, van der Torre J, Scheffner M, Alemany R, Winald R Gerritsen, Chris JLM Meijer, Peter JF Snijders, Victor W van Beusechem. Oncolytic
adenovirus expressing a p53 variant resistant to degradation by HPVE6 protein exhibits potent and selective replication in cervical cancer. Mol Ther.
2005 Dec;12(6):1083-90.
Steenbergen RDM, de Wilde J, Wilting SM, Brink AATP, Snijders PJF, Meijer CJLM. 2005. HPV-mediated transformation of the anogenital tract (review). J.Clin.Virol.
325: S25-S33
Steenbergen RDM, Kramer D, Braakhuis BJM, Stern PL, Verheijen RHM, Meijer CJLM, Snijders PJF TSLC1 gene silencing in cervical cancer cell lines and in cervical
neoplasia. J. Natl. Cancer Inst. 2004, 96, 294-305
Van Duin M, Steenbergen RDM,De Wilde J, Helmerhorst ThJ, Verheijen RHM, Risse EKJ, Meijer CJLM, Snijders PJF. Telomerase activity in high-grade cervical lesions
is associated with allelic imbalance at 6q14-22. Int.J.Cancer 2003, 105, 577-582.
Steenbergen RDM, Oude Engberink VE, Kramer D, Schrijnemakers HFJ, Verheijen RHM, Meijer CJLM, Snijders PJF. Downregulation of GATA-3 expression during HPV-mediated
immortalization and cervical carcinogenesis. Am.J.Pathol 2002, 160, 1945-1951.
Steenbergen RDM, Kramer D, Meijer CJLM, Walboomers JMM, Trott DA, Cuthbert AP, Newbold RF, Overkamp WJI, Zdzienicka MZ, and Snijders PJF. Telomerase suppression by
chromosome 6 in an HPV16 immortalized keratinocyte cell line and a cervical cancer cell line. J. Natl. Cancer Inst.,2001,93 (11), 865-872 .
Steenbergen RDM, Parker JN, Isern S, Walboomers JMM, Meijer CJLM, Snijders PJF, Broker TR, Chow LT - Viral E6/E7 transcription in the basal layer of organotypic
cultures without apparent p21cip1 protein precedes immortalization of human papillomavirus type 16- and 18-transfected human keratinocytes. J Virol 1998; 72: 749-757.
Steenbergen RDM, Walboomers JMM, Meijer CJLM, van der Raaij-Helmer EMH, Parker JN, Chow LT, Broker TR, Snijders PJF - Transition of human papillomavirus type
16 and 18 tranfected human foreskin keratinocytes towards immortality: Activation of telomerase and allele loss at 3p, 10p, 11q and/or 18q.
Oncogene 1996; 13: 1249-1257.
Contact Details
Renske D.M. Steenbergen
Dept of Pathology, Unit of Molecular Pathology
VU University medical center
PO Box 7057
1007 MB Amsterdam
Tel. 31-20-4442331
Email
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