RNAi Global Initiative - German Cancer Research Center, DKFZ

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German Cancer Research Center, DKFZ

	Stefan Wiemann

	The Group of Dr. Stefan Wiemann is part of the Division of Molecular Genome Analysis (Prof. Annemarie Poustka) at the German Cancer Research Center (DKFZ) in Heidelberg. We systematically generate and exploit genomics resources to identify novel players in cancer development and progression. Having been instrumental in the identification of human genes and in the generation of human ORF clones, the group utilizes these to overexpress the encoded proteins, to complement the systematic downregulation of endogenous genes via RNAi. We functionally analyze gene and protein function in a variety of cellular assays, with main emphasis on identifying modulators of the cell cycle and cell migration. The project “SMP-Cell” is funded within the National Genome Research Network (NGFN) by the German Federal Ministry of Education and Research. For more information visit the Molecular Genome Analysis webpage and the SMP-Cell webpage.

	Recent Publications Mehrle, A., Rosenfelder, H., Schupp, I., Del Val, C., Arlt, D., Hahne, F., Bechtel, S., Simpson, J. C., Hofman, O., Hide, W., et al. (2006). The LIFEdb database in 2006. Nucleic Acids Res 34:D415-418. Arlt, D., Huber, W., Liebel, U., Schmidt, C., Majety, M., Sauermann, M., Rosenfelder, H., Bechtel, S., Mehrle, A., Bannasch, D., et al. (2005). Functional Profiling: From Microarrays via Cell-Based Assays to Novel Tumor Relevant Modulators of the Cell Cycle. Cancer Res 65:7733-7742. Imanishi, T., Itoh, T., Suzuki, Y., O'Donovan, C., Fukuchi, S., Koyanagi, K. O., Barrero, R. A., Tamura, T., Yamaguchi-Kabata, Y., Tanino, M., et al. (2004). Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones. PLoS Biol 2:856-875. Starkuviene, V., Liebel, U., Simpson, J. C., Erfle, H., Poustka, A., Wiemann, S., and Pepperkok, R. (2004). High-content screening microscopy identifies novel proteins with a putative role in secretory membrane traffic. Genome Res 14:1948-1956. Wiemann, S., Arlt, D. H., Huber, W., Wellenreuther, R., Schleeger, S., Mehrle, A., Bechtel, S., Sauermann, M., Korf, U., Pepperkok, R., et al. (2004). From ORFeome to biology: a functional genomics pipeline. Genome Res 14:2136-2144. Back to DKFZ