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German Cancer Research Center, DKFZ
 

Stefan Wiemann

Stefan Wiemann heads the Division of Molecular Genome Analysis at the German Cancer Research Center (DKFZ) in Heidelberg. We systematically generate and exploit genomics resources to identify novel players in cancer development and progression.

Having been instrumental in the identification of human genes and in the generation of human ORF clones and utilize these to overexpress the encoded proteins. This complements the phenotypic analysis in cellular screening via systematic downregulation of endogenous genes via RNAi. We functionally analyze gene and protein function in a variety of cellular assays, with main emphasis on identifying modulators of cellular signaling (ErbB-network in breast cancer) and cell migration.

The project “Cellular Systems Genomics (IG-CSG)” is funded within the National Genome Research Network (NGFN) by the German Federal Ministry of Education and Research.

For more information visit the Molecular Genome Analysis webpage and the IG-CSG webpage.

 
 
 
Recent Publications

Sahin, O., Froehlich, H., Loebke, C., Korf, U., Burmester, S., Majety, M., Thieffry, D., Chaouiya, C., Poustka, A., Wiemann, S., Beissbarth, T. & Arlt, D. (2009) Modeling of ErbB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance. BMC Systems Biology 3, 1.

Sahin, O. & Wiemann, S. (2009) Functional Genomics and Proteomics approaches to study the ErbB-network in cancer. FEBS Lett 583, 1766-1771.

Zhang, J. D. & Wiemann, S. (2009) KEGGgraph: a graph approach to KEGG PATHWAY in R and Bioconductor. Bioinformatics 25, 1470-1471.

Taylor, C. F., Field, D., Sansone, S. A., Aerts, J., Apweiler, R., Ashburner, M., Ball, C. A., Binz, P. A., Bogue, M., Booth, T., Brazma, A., Brinkman, R. R., Michael Clark, A., Deutsch, E. W., Fiehn, O., Fostel, J., Ghazal, P., Gibson, F., Gray, T., Grimes, G., Hancock, J. M., Hardy, N. W., Hermjakob, H., Julian, R. K., Jr., Kane, M., Kettner, C., Kinsinger, C., Kolker, E., Kuiper, M., Novere, N. L., Leebens-Mack, J., Lewis, S. E., Lord, P., Mallon, A. M., Marthandan, N., Masuya, H., McNally, R., Mehrle, A., Morrison, N., Orchard, S., Quackenbush, J., Reecy, J. M., Robertson, D. G., Rocca-Serra, P., Rodriguez, H., Rosenfelder, H., Santoyo-Lopez, J., Scheuermann, R. H., Schober, D., Smith, B., Snape, J., Stoeckert, C. J., Jr., Tipton, K., Sterk, P., Untergasser, A., Vandesompele, J. & Wiemann, S. (2008) Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project. Nat Biotechnol 26, 889-96.

Sahin, O., Löbke, C., Korf, U., Appelhans, H., Sultmann, H., Poustka, A., Wiemann, S. & Arlt, D. (2007) Combinatorial RNAi strategy: The next generation of quantitative protein network analysis. Proc Natl Acad Sci U S A 104, 6579-6584.

Sauermann, M., Hahne, F., Schmidt, C., Majety, M., Rosenfelder, H., Bechtel, S., Huber, W., Poustka, A., Arlt, D. & Wiemann, S. (2007) High throughput FACS based assay to identify apoptosis inducing proteins. J. Biomol Screening 12, 510-20.




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