RNAi Global Initiative - University of Nebraska Medical Center Eppley Cancer Center

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UNMC Eppley Cancer Center

	The mission of the University of Nebraska Medical Center (UNMC) Eppley Cancer Center is to coordinate basic research and clinical cancer research, patient care and educational programs and to facilitate application of new knowledge about the etiology, diagnosis, treatment and prevention of cancer and to improve health and quality of life. Kenneth H. Cowan, M.D., Ph.D., is Director of the Eppley Cancer Center and the Eppley Institute for Research in Cancer and Allied Diseases at UNMC. The UNMC Eppley Cancer Center is a National Cancer Institute (NCI) designated cancer center, conducting multidisciplinary basic and clinical/translational cancer research. It is the only NCI-designated cancer center in the state of Nebraska. In fact, the UNMC Eppley Cancer Center is one of only 61 NCI-designated centers in the country and the only NCI-designated cancer center in the central region of the U.S. from North Dakota to Texas. The Cancer Center, which was initially established in 1983, utilizes and incorporates the expertise and resources from each of the Colleges and Institutes that comprise the University of Nebraska Medical Center as well as its affiliated hospital (The Nebraska Medical Center). The Cancer Center also integrates cancer research resources from other academic units of the University of Nebraska (University of Nebraska-Lincoln and the University of Nebraska-Omaha). The UNMC Eppley Cancer Center is a founding member of the National Comprehensive Cancer Network (NCCN), an alliance of 19 of the world's leading cancer centers that develop standards and set guidelines for treating patients. This means the most current and ground-breaking treatment options are available to our patients through the translation of cutting-edge research into state-of-the-art care. Cancer Center physicians and scientists work together to quickly translate discoveries made in the laboratory to innovative treatments for the patient in a caring and compassionate manner.	UNMC Eppley Cancer Center Research and Patient Care The UNMC Eppley Cancer Center is renowned for its basic research programs in chemical carcinogenesis, molecular, cellular and structural biology, and translational research in new therapies. Promising areas of clinical research include investigating antibodies for diagnosing and treating lymphomas and solid tumors, and developing tumor vaccines for colon and breast cancer, to name a few. Researchers and physicians at the UNMC Eppley Cancer Center are working to learn about the causes of cancer and to find better ways to diagnose and treat these diseases. The Cancer Center is nationally and internationally recognized for its excellence in cancer research, treatment and patient care. People from all 50 states and 19 foreign countries come to the cancer center seeking treatment and hope. Patients choose the center for its internationally-recognized health care professionals, biomedical research, patient care, translational research opportunities, clinical trials, and education programs.

Genome-Wide RNAi Global Initiative
We plan to take advantage of the genome wide siRNA approach and uncover critical components in pathways that contribute to tumor formation and cancer therapy.

Combined with the Cancer Center's programs in structural biology, bioinformatics, and clinical research, the findings from the siRNA screenings will make significant contributions to the prognosis, diagnosis and treatment of cancer.

RNAi Global Principal Investigators:
Kenneth Cowan
David Kelly
Robert Lewis
M.A. (Tony) Hollingsworth
Xu Luo