RNAi Global Initiative - Vrije University Medical Center (VUMC)

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Vrije University Medical Center (VUMC)

	The VU Medical Center (VUmc) has been known by this name since January 2001, when the Academic Hospital and the Faculty of Medicine of the Vrije Universiteit Amsterdam were integrated. As an academic center, the VUmc is specialized in helping patients with uncommon clinical pictures and those who require highly intensive and complex care. The VUmc offers tertiary clinical care and referral-center care in certain areas. This often involves unique diagnosis and treatment, and specialized research. The VUmc contributes to the maintenance and improvement of public health by conducting research, disseminating new knowledge, and by educating a new generation of care providers. The scientific research at VUmc is based on five pivotal points, which are embodied by multidisciplinary research institutes. Research in the area of cancer and immunology is organized in the VUmc Institute for Cancer and Immunology (V-ICI). V-ICI participates in two research and graduate schools accredited by the Royal Netherlands Academy of Arts and Sciences, i.e., the Oncology Graduate School Amsterdam and the Amsterdam-Leiden Institute for Immunology. The VUmc Cancer Center Amsterdam (CCA) is the cancer expertise center of the VUmc. The CCA aims to provide the best possible care and treatment to patients with cancer. To this end, the CCA integrates and strengthens oncology expertise at the VUmc, stimulating translation of basic research programs into clinical useful tools and methods. In 2006, CCA and V-ICI merged and opened a new research building where most basic and translational oncology research being conducted at VUmc is clustered. In addition, it was decided to complement existing core facilities for microarray and proteomics research by establishing a core facility for RNAi library screening. This RNA Interference Functional Oncogenomics Laboratory (RIFOL) was set up with financial support from the Foundation SBGO, one of the foundations supporting CCA/V-ICI. The RIFOL serves a wide range of labs at VUmc and represents VUmc as member of the RNAi Global Initiative. For further information, visit our website at http://www.vumc.nl/.	VU Medical Center VUmc Cancer Center Amsterdam
	RNAi Global Principal Investigators: Victor W. van Beusechem, Ph.D. Dept. Medical Oncology, Gene Therapy Group/RIFOL Identification of genes involved in oncolytic virus replication in cancer cells. Web Email Frank A.E. Kruyt, Ph.D. Dept. Medical Oncology, Apoptosis Group Dissecting apoptotic pathways in cancer, in particular non-small cell lung cancer, for the development and design of improved therapeutic strategies. Identification of key apoptotic targets in NSCLC by RNAi library screening. Web Email Gerrit A. Meijer, MD Ph.D. Dept. Pathology, Tumor Profiling Unit Identification of genes that drive colon adenoma-to-carcinoma progression. Web Email Renske D.M. Steenbergen, Ph.D. Dept. Pathology, Molecular Pathology Unit Elucidation of human papillomavirus (HPV)-mediated carcinogenesis of the uterine cervix and translation of this basic knowledge into novel approaches for prevention and treatment of cervical cancer. Email Ruud H. Brakenhoff, Ph.D. Dept. Otolaryngology/Head and Neck Surgery Identification of genes involved in HNSCC carcinogenesis and genes modulating chemoradiation resistance in head and neck cancer Email	Jacqueline Cloos, Ph.D. Dept. Pediatric Oncology/Hematology Find new treatment targets in relevant signal transduction pathways for innovative therapy of leukemia. Web1, Web2 Email Johan de Winter, Ph.D. Dept. Clinical Genetics Chromosomal instability and cancer, with a focus on inherited cancer predisposition syndromes. Email Teunis B.H. Geijtenbeek, Ph.D. Dept. Molecular Cell Biology and Immunology Defining molecular mechanisms of immune subversion by pathogens and tumors. Email Thomas Wurdinger, Ph.D. Dept. Neurosurgery, Neuro-ocology Research Group (NRG) Identification of genes involved in brain tumor systems. Email Primary Contact Information: Victor W. van Beusechem, Ph.D. RNAi Functional Oncogenomics Laboratory Department of Medical Oncology Phone: +31.20.444.2162 Fax: +31.20.444.2126 Web Email Institutional Contact: Ans Buijs and Joke van Diemen Office of the Director Dr. W.R. Gerritsen VUmc CCA / V-ICI Phone: +31 20 4444 342 or +31 20 4444 356 Fax: +31 20 4444 081 Email